Semiotics is an increasingly fluid methodology moving across different academic and commercial boundaries. There is no doubt that Semiotics has gained popularity in the business sector, helping brands to initiate and develop cultural transformations. Its role is constantly evolving and becoming pivotal in the development of new commercial research methodologies. Design, anthropological and semiotic methods are widely known in the fields of market research, branding, communications and strategy. Each discipline has developed tools that are unique to their own practices e.g. design thinking, ethnography, semiotic square, among others. At the same time, the emergence of approaches such as Design Semiotics and Ethno-Semiotics are becoming popular among business for their usefulness to discern cultural and technological shifts. However, new semiotician roles need to emerge and bring a symbiotic relationship between disciplines to understand deeper the future commercial ecosystems and leveraging attitudes towards change and cultural transformations. The development and integration of thinking, tools and theories from design, anthropology and semiotics are paving the way to the next generation of semioticians capable of speaking across multi-disciplinary arenas but still with deep expertise in a discipline(s), in addition to working at the intersection, fulfilling the technological and cultural future demands for production and consumption of signs. This presentation will explore in parallel the trajectories of Design Semiotics and Ethno-Semiotics in applied commercial practices, the current challenges presented and the opportunities for the development of emergent semiotic roles based on the power of convergence and intersectionality. The premise of this paper is to demonstrate the value of semiotics, working in the intersection between disciplines, particularly around the contexts of Design and Anthropology. This paper will briefly acknowledge the historical movement of scholarship and theoretical approaches around semiotics used in both design and anthropology, discuss the dynamics of influence, and illustrate emerging semiotician roles that can potentially exist. The grounds for this paper are the academic and commercial experience of the author in the fields of design, semiotics and anthropology, mainly working in intersectional spaces in the United Kingdom and globally, providing semiotics, design and cultural analysis for local and global brands, in a wide range of categories. Languages : English and Spanish